![]() Mr Chan presented this data at a scientific conference (Asian Pacific Society of Respirology) in November 2007. This project was completed by our research student John Ho Chan whilst working at the MRI as an Undergraduate Research Opportunity Programme Scholar. We are now measuring this index in people with asthma and chronic obstructive pulmonary disease. An elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis. ![]() The results supported our hypothesis because even though the subjects were young and had normal lung function our index of flow-dependence was able to differentiate between subjects with normal and 'super' normal lung function. ![]() Our subjects were healthy young adults with normal lung function. We have now completed a study to test the hypothesis that this flow-dependence of anatomical dead space provides a sensitive physiological index of abnormal airway function. We have previously shown that volume of the lung airways (anatomical dead space) varies with expired flow.
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